A Basic Biochemical Approach to Addressing Chronic Kidney Disease

Plain-Language Summary

This published research paper, co-authored by Stephen McConnell, describes a combination of niacin, sodium bicarbonate, calcium carbonate, and isoquercetin used to address later-stage chronic kidney disease. The authors tracked kidney function markers in a group of patients over six months and report on the biochemical reasoning behind the approach, including its effect on phosphate levels, acidosis, and protein in the urine.

Key Concepts

• Co-authored by Stephen McConnell, W. Todd Penberthy, Richard Chern, and Chester H. Fox.
• Published in the Journal of Orthomolecular Medicine, Volume 40, Number 1.
• Describes a formulation combining niacin, sodium bicarbonate, calcium carbonate, and isoquercetin for CKD stages 3B–5.
• Tracks eGFR and urine albumin-creatinine ratio at baseline, 3 months, and 6 months across a documented patient cohort.

Stephen's Role

Co-Author

Citation

Penberthy, W. T., McConnell, S., Chern, R., & Fox, C. H. (2025). A basic biochemical approach to addressing chronic kidney disease. Journal of Orthomolecular Medicine, 40(1).

External Source