Kidney Health Approach

A biochemical approach to chronic kidney disease

Stephen D. McConnell's framework connects kidney function, metabolic health, lipid metabolism, niacin research, and sodium bicarbonate research into one educational picture. Each point below is labeled so you can see what's published evidence, what's Stephen's interpretation, and what's still an open question.

Chronic kidney disease

  • Published ResearchChronic kidney disease (CKD) is a well-documented, progressive loss of kidney function with established diagnostic markers such as eGFR and creatinine trends.
  • Educational RecommendationUnderstanding your own lab trends over time, not just a single reading, is a useful starting point for kidney-health education.

Kidney function and metabolic health

  • Stephen's InterpretationStephen views kidney function as closely tied to broader metabolic health, rather than an isolated organ system.
  • Educational RecommendationMetabolic markers (blood sugar, lipids, blood pressure) are worth tracking alongside kidney-specific labs.

Niacin research

Stephen's interest in niacin grew out of his broader lipidology background. His ongoing work focuses on how niacin, often combined with sodium bicarbonate, may support kidney function in chronic kidney disease — including how to manage flushing, a common reaction some people notice when starting niacin.

Visit the Niacin Resource Center → for the full flushing-management guide, titration protocol, scientific evidence, and FAQ.

Sodium bicarbonate research

  • Published ResearchSodium bicarbonate's role in managing metabolic acidosis in CKD has been studied in the published nephrology literature.
  • Emerging HypothesisStephen's ongoing work explores how sodium bicarbonate may complement other kidney-health strategies, alongside niacin, as an area for continued study.

Lipid metabolism

  • Published ResearchAs a lipid specialist, Stephen's core training is in lipid metabolism and its downstream effects on cardiovascular and renal health.
  • Stephen's InterpretationHe views lipid management as a foundational piece of a broader kidney-health strategy, not a standalone fix.

Blood pressure and vascular health

  • Published ResearchBlood pressure control is a well-established factor in slowing CKD progression.
  • Educational RecommendationRegular blood pressure monitoring, in coordination with a physician, is encouraged as part of any kidney-health strategy.

Nutrition and lifestyle

  • Educational RecommendationDiet, hydration, and lifestyle habits are discussed as supportive factors alongside, not instead of, medical care.
  • ObservationStephen has observed that consistent, sustainable habits tend to matter more than short-term dietary extremes.

Patient education

  • Educational RecommendationA core part of Stephen's mission is translating research and lab data into language patients can actually use in conversations with their care team.

Monitoring and medical supervision

  • Educational RecommendationAny changes to diet, supplements, or medication should be introduced gradually and reviewed with a qualified healthcare provider, with regular lab monitoring.

Read the research behind this approach

Every topic above connects to Stephen's published research and articles, including "A Basic Biochemical Approach to Addressing Chronic Kidney Disease" and "Reversing Chronic Kidney Disease with Niacin and Sodium Bicarbonate."

Frequently Asked

Common questions

What is Stephen's approach to niacin and kidney health?

Stephen studies how niacin, combined with sodium bicarbonate, may support kidney function in chronic kidney disease. His work with W. Todd Penberthy and colleagues is documented in the Research Library, including dosing, mechanisms, and case findings.

What causes niacin flushing, and how is it managed?

Flushing is a common reaction caused by niacin dilating blood vessels near the skin. Stephen's educational guidance covers dosing, timing, food, and hydration strategies for managing it, and recommends starting under medical supervision, especially with existing kidney or liver conditions.

What role does sodium bicarbonate play in Stephen's kidney-health approach?

Sodium bicarbonate is used to help manage metabolic acidosis in chronic kidney disease. Stephen's research explores how it works alongside niacin as part of a broader biochemical approach to kidney health.

This page is educational and does not constitute individualized medical advice. See the Medical Disclaimer for details. Site: https://stephendmcconnell.com